Initial Draft Report: OECD validation Phase 1 (Optimisation) for the Amphibian Metamorphosis Assay

The purpose of this document is to summarize the results of an international round of testing and research aimed at developing and optimizing an amphibian-based screening assay for thyroid axis disruption. This effort originated at a meeting of the Amphibian Expert Group, an advisory group to the Validation Management Group, in June 2003 at a meeting hosted by the US Environmental Protection Agency in Duluth, MN, USA.