Cover des Berichts "New-Generation Steroid Hormones"
Chemicals

New-Generation Steroid Hormones

Tailored Assessment Strategies for Environmental Protection


The project generated ecotoxicological data needed for the development of a tailored testing strategy to assess the environmental risk of pharmaceuticals (progestins and glucocorticoids). For this purpose, chronic fish tests, among others, were carried out in the laboratory according to a new test protocol currently undergoing ⁠OECD⁠ validation investigating dienogest and dexamethasone as test substances. The studies provided reliable and valid results with effect thresholds in the lower µg/L or ng/L range. This has closed data gaps for the development of new assessment approaches for a targeted risk assessment of specifically acting pharmaceuticals. Additional investigations on directed gene expression and immunosuppressive effect assays would complement the assessment strategy for progestins and glucocorticoids.

Reihe
Texte | 57/2024
Seitenzahl
117
Erscheinungsjahr
Autor(en)
Dr. Matthias Teigeler, Dr. Kornelija Franzen, Dr. Elke Eilebrecht, Dr. Dirk Schaudien, Prof. Dr. Christoph Schäfers
Sprache
Englisch
Forschungskennzahl
3717 67 405 0
Verlag
German Environment Agency
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Dateigröße
2518 KB
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0,00 €
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Schlagworte:
 endocrine active substance  biological effect  ecotoxicology  environmental risk assessment