Sensor cell lines have been developed to monitor rapid non-genomic signalling cascades influenced by endocrine-active substances. These in-vitro bioassays were created by genetically modifying G-protein coupled estrogen receptor (GPER1) expressing cells to become artificial fluorescent signalosomes. Both GPER1 agonists and antagonistic compounds were used to characterize the respective sensor cells. The bioassays were then used to screen for potential endocrine-disrupting substances. In addition, these assays have been used to evaluate influent and effluent from advanced treatment units in several wastewater treatment plants.
Chemikalien
Further development of test methods for hormonally active pharmaceuticals and other substances
Reihe
Texte | 132/2024
Seitenzahl
104
Erscheinungsjahr
Autor(en)
Dr. Manfred Frey, Finnian Freeling
Sprache
Englisch
Forschungskennzahl
3720 64 405 0
Verlag
German Environment Agency
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6100 KB
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