As tools for environmental monitoring of pharmaceuticals, mode of action -based in vitro-assays were developed for beta-blockers as metoprolol, and non-steroidal anti-inflammatory drugs, as diclofenac. In order to validate these tests for their suitability to reflect in vivo-effects in aquatic organisms, toxicity tests and biomarker studies were conducted with fish, crustaceans, snails and sediment-dwelling invertebrates. Test were conducted in laboratory, aquatic mesocosm and under field conditions. In addition to population relevant endpoints individual health parameters were determined by means of stress protein analyses, histological investigations and studies revealing oxidative stress.
EFF-Pharm: Effects of pharmaceuticals (nonsteroidal anti-inflammatory drugs and beta-blockers) in fish and invertebrates and their detection by newly developed in vitro-bioassays
Texte | 44/2017
Rita Triebskorn, Simon Schwarz, Hannah Schmieg, Heinz-R. Köhler, Dirk Jungmann, Kristin Berg, Anna Buchberger, Manfred Frey, Marco Scheurer, Frank Sacher, Matthias Oetken, Jörg Oehlmann
3713 63 4102, 3715 63 412
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