Cover_TEXTE_94-2020_Development of an OECD Guidance Document for the Application of OECD Test Guideline 236
Chemikalien

Development of an OECD Guidance Document for the Application of OECD Test Guideline 236 (Acute Fish Embryo Toxicity Test)


The project goal was to support the regulatory acceptance of data generated with the OECD Acute Fish Embryo Toxicity Test (TG 236) as alternative method to the OECD Acute Fish Toxicity Test (TG 203). TG 236 is an important contribution to animal welfare in chemical safety assessment in Europe but also worldwide. Results of the project are directly used within OECD project 2.54 on the Development of a Guidance Document for an Integrated Approach to Testing and Assessment of Acute Fish Toxicity. Specific results: (1) the knowledge on xenobiotic transformation capacities in zebrafish embryos, juveniles and adults is fragmentary. Therefore, transfer of biotransformation data from juvenile fish to adult fish does not appear justified. (2) The chorion is no barrier for uncharged industrial chemicals of a molecular size of 3,000 – 4,000 Da.

Reihe
Texte | 94/2020
Seitenzahl
106
Erscheinungsjahr
Autor(en)
Prof. Dr. Thomas Braunbeck, Dr. Svenja Böhler, Dr. Susanne Knörr, Ann-Kathrin Lörracher, Dr. Katharina Pelka, Dr. Britta Kais
Sprache
Englisch
Forschungskennzahl
3715674190
Verlag
Umweltbundesamt
Zusatzinfo
PDF ist barrierefrei
Dateigröße
12727 KB
Preis
0,00 €
Druckversion
nicht lieferbar
Als hilfreich bewertet
1
Teilen:
Artikel:
Drucken Senden
Schlagworte:
 Acute Fish Embryo Toxicity  TG 236  chemical safety