Cover Texte 41/2016 Novel assessment methods in ecotoxicology for the identification of hormonal active substances: Combining the fish sexual development test with gene expression endpoints
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Novel assessment methods in ecotoxicology for the identification of hormonal active substances: Combining the fish sexual development test with gene expression endpoints


For the evaluation of effects of hormone-active substances to fish, several test guidelines have been validated by the OECD which are included in the Conceptual Framework for Testing and Assessment of Endocrine Disruptors (OECD, 2010). In these tests, the assessment of physiological parameters is limited to the established biomarkers like vitellogenin or 11-keto testosterone in blood plasma or liver tissue. A promising approach
to refine existing testing strategies is the integration of molecular endpoints, which rapidly respond to exposure. Furthermore, these endpoints can be indicative of potential adverse effects at the organismal level by providing information, which connect to the initiating effect of a substance. This is in line with the concept of Adverse Outcome Pathways (AOP), which evolved from the “toxicity pathway” approach as a mechanistic evaluation tool for the risk assessment.

Series
Texte | 41/2016
Number of pages
188
Year of publication
Author(s)
Dr. Elke Muth-Köhne, Matthias Teigeler, Dr. Martina Fenske
Language
Englisch
Project No. (FKZ)
3712 63 418
Publisher
Umweltbundesamt
File size
4945 KB
Price
0,00 €
Print version
not available
rated as helpful
84