Cover des Berichts "New-Generation Steroid Hormones"
Chemicals

New-Generation Steroid Hormones

Tailored Assessment Strategies for Environmental Protection


The project generated ecotoxicological data needed for the development of a tailored testing strategy to assess the environmental risk of pharmaceuticals (progestins and glucocorticoids). For this purpose, chronic fish tests, among others, were carried out in the laboratory according to a new test protocol currently undergoing OECD validation investigating dienogest and dexamethasone as test substances. The studies provided reliable and valid results with effect thresholds in the lower µg/L or ng/L range. This has closed data gaps for the development of new assessment approaches for a targeted risk assessment of specifically acting pharmaceuticals. Additional investigations on directed gene expression and immunosuppressive effect assays would complement the assessment strategy for progestins and glucocorticoids.

Series
Texte | 57/2024
Number of pages
117
Year of publication
Author(s)
Dr. Matthias Teigeler, Dr. Kornelija Franzen, Dr. Elke Eilebrecht, Dr. Dirk Schaudien, Prof. Dr. Christoph Schäfers
Language
English
Project No. (FKZ)
3717 67 405 0
Publisher
German Environment Agency
Additional information
PDF is accessible
File size
2518 KB
Price
0,00 €
Print version
not available
rated as helpful
30
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Tags:
 endocrine active substance  biological effect  ecotoxicology  environmental risk assessment