Cover of report "Further development of test methods for hormonally active pharmaceuticals and other substances"
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Further development of test methods for hormonally active pharmaceuticals and other substances


Sensor cell lines have been developed to monitor rapid non-genomic signalling cascades influenced by endocrine-active substances. These in-vitro bioassays were created by genetically modifying G-protein coupled estrogen receptor (GPER1) expressing cells to become artificial fluorescent signalosomes. Both GPER1 agonists and antagonistic compounds were used to characterize the respective sensor cells. The bioassays were then used to screen for potential endocrine-disrupting substances. In addition, these assays have been used to evaluate influent and effluent from advanced treatment units in several wastewater treatment plants.

Series
Texte | 132/2024
Number of pages
104
Year of publication
Author(s)
Dr. Manfred Frey, Finnian Freeling
Language
English
Project No. (FKZ)
3720 64 405 0
Publisher
German Environment Agency
Additional information
PDF is accessible
File size
6100 KB
Price
0,00 €
Print version
not available
rated as helpful
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Tags:
 in vitro  Biotest  endocrine active substance  pharmaceutical  hormone