The ECHA Guidance Documents R.12 to R.18 include detailed provisions on how to conduct an exposure assessment as part of the Chemical Safety Report. The guidance documents, however, only restrictedly address the consideration of a substance’s emissions into the environment, if the local releases from various uses of the same substance result in a cumulative exposure. In a situation where a chemical has a number of applications in one site, it may however occur that the emissions of several uses which only have a low risk if considered separately will sum up and cause an unacceptable risk to the environment.