The German Environment Agency initiated a project to promote nature-based solutions (NbS) in the Alpine region. The aim is to highlight the importance of NbS for biodiversity, climate protection and adaptation, and to analyze political and cross-sectoral governance mechanisms for the Alpine Convention (AC) region. Eight pilot projects from seven AC countries were examined to identify success factors and challenges. The results confirm that NbS can make an important contribution to climate protection, climate adaptation, and biodiversity conservation in the Alps. This requires a clear legal framework, innovative financing mechanisms, and cooperative governance models. This publication serves as a basis for future strategies within the framework of the Alpine Convention.