Cover of publication 44/2017 fish and invertebrates and their detection by newly developed in vitro-bioassays
Chemicals

EFF-Pharm: Effects of pharmaceuticals (nonsteroidal anti-inflammatory drugs and beta-blockers) in fish and invertebrates and their detection by newly developed in vitro-bioassays


As tools for environmental monitoring of pharmaceuticals, mode of action -based in vitro-assays were developed for beta-blockers as metoprolol, and non-steroidal anti-inflammatory drugs, as diclofenac. In order to validate these tests for their suitability to reflect in vivo-effects in aquatic organisms, toxicity tests and biomarker studies were conducted with fish, crustaceans, snails and sediment-dwelling invertebrates. Test were conducted in laboratory, aquatic mesocosm and under field conditions. In addition to population relevant endpoints individual health parameters were determined by means of stress protein analyses, histological investigations and studies revealing oxidative stress.

Reihe
Texte | 44/2017
Seitenzahl
310
Erscheinungsjahr
Autor(en)
Rita Triebskorn, Simon Schwarz, Hannah Schmieg, Heinz-R. Köhler, Dirk Jungmann, Kristin Berg, Anna Buchberger, Manfred Frey, Marco Scheurer, Frank Sacher, Matthias Oetken, Jörg Oehlmann
Sprache
Englisch
Forschungskennzahl
3713 63 4102, 3715 63 412
Verlag
Umweltbundesamt
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11779 KB
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Schlagworte:
 pharmaceutical  NSAID  beta-blocker  in vitro assay  fish test  invertebrate  Biomarker  Biotest