Publikation:Comparative analysis of estimated and measured BCF data (OECD 305) - Literature study with a special focus on differential accumulation of (mixtures of) stereoisomers
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Comparative analysis of estimated and measured BCF data (OECD 305)

Literature study with a special focus on differential accumulation of (mixtures of) stereoisomers


Bioaccumulation potential of chemicals is frequently assessed from bioconcentration, conventionally measured according to ⁠OECD⁠ 305 (Bioaccumulation: Flow-through Fish Test) (OECD,1996) and expressed as Bioconcentration Factor (BCF). These studies deliberately reduce the manifold uptake and elimination mechanisms in aquatic organisms to respiratory absorption via gills and diffusion through the skin (e.g. Arnot and Gobas, 2003; Sijm et al. 2007). Despite the simplifications, testing costs are high and a minimum of 108 fish are consumed in each OECD 305 bioconcentration guideline study (ILSI HESI, 2006).

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Texte | 15/2011
Seitenzahl
59
Erscheinungsjahr
Autor(en)
Dr. Martin Müller, Dr. Monika Nendza
Sprache
Englisch
Forschungskennzahl
360 04 024
Verlag
Umweltbundesamt
Dateigröße
3219 KB
Preis
0,00 €
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Schlagworte:
 bioconcentration  bioconcentration factor  accumulation  QSAR  Stereoisomer