Cover of publication 44/2017 fish and invertebrates and their detection by newly developed in vitro-bioassays
Chemicals

EFF-Pharm: Effects of pharmaceuticals (nonsteroidal anti-inflammatory drugs and beta-blockers) in fish and invertebrates and their detection by newly developed in vitro-bioassays


As tools for environmental monitoring of pharmaceuticals, mode of action -based in vitro-assays were developed for beta-blockers as metoprolol, and non-steroidal anti-inflammatory drugs, as diclofenac. In order to validate these tests for their suitability to reflect in vivo-effects in aquatic organisms, toxicity tests and biomarker studies were conducted with fish, crustaceans, snails and sediment-dwelling invertebrates. Test were conducted in laboratory, aquatic mesocosm and under field conditions. In addition to population relevant endpoints individual health parameters were determined by means of stress protein analyses, histological investigations and studies revealing oxidative stress.

Series
Texte | 44/2017
Number of pages
310
Year of publication
Author(s)
Rita Triebskorn, Simon Schwarz, Hannah Schmieg, Heinz-R. Köhler, Dirk Jungmann, Kristin Berg, Anna Buchberger, Manfred Frey, Marco Scheurer, Frank Sacher, Matthias Oetken, Jörg Oehlmann
Language
Englisch
FKZ
3713 63 4102, 3715 63 412
Publisher
Umweltbundesamt
Additional information
PDF ist barrierefrei
File size
11779 KB
Price
0,00 €
Print version
not available
rated as helpful
23